|
Squamous cell carcinoma of the head and neck
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Squamous cell carcinoma of the head and neck
|
0.710 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Squamous cell carcinoma of lip
|
0.300 |
SomaticCausalMutation
|
disease |
ORPHANET |
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
|
10866301 |
2000 |
|
Squamous cell carcinoma of oropharynx
|
0.300 |
SomaticCausalMutation
|
disease |
ORPHANET |
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
|
10866301 |
2000 |
|
Squamous cell carcinoma of the hypopharynx
|
0.300 |
SomaticCausalMutation
|
disease |
ORPHANET |
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
|
10866301 |
2000 |
|
Laryngeal Squamous Cell Carcinoma
|
0.300 |
SomaticCausalMutation
|
disease |
ORPHANET |
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
|
10866301 |
2000 |
|
Squamous cell carcinoma of mouth
|
0.300 |
SomaticCausalMutation
|
disease |
ORPHANET |
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
|
10866301 |
2000 |
|
Malignant neoplasm of stomach
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
A significant decrease in p33(ING1) expression was evident in 15 of 20 gastric cancers.
|
10660101 |
1999 |
|
Malignant neoplasm of stomach
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
However, there has been no report on the prognostic significance of the ING1 expression level in human cancers, though the expression of the wild-type ING1 gene is significantly decreased in breast, lymphoid and gastric cancers as compared with their corresponding normal tissues.
|
15375504 |
2004 |
|
Squamous cell carcinoma
|
0.160 |
AlteredExpression
|
disease |
BEFREE |
Twenty-six of 28 oral squamous cell carcinomas (SCCs) expressed p33ING1 mRNA.
|
12063558 |
2002 |
|
Squamous cell carcinoma
|
0.160 |
AlteredExpression
|
disease |
BEFREE |
GAPDH mRNA expression was detectable in 12 out of 21 oral squamous cell carcinoma (SCC) samples. p21WAF1 mRNA expression was detectable in 5 out of 12 SCC samples, MDM2 mRNA expression was detectable in 5 our of 12 SCC samples and p33ING1 mRNA expression was detectable in 6 out of 12 SCC samples.
|
12926130 |
2003 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that Src may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src expression or activity are present.
|
23585863 |
2013 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ING1 overexpression also blocked cancer cell metastasis in vivo and eliminated tumor-induced mortality in mouse models.
|
24962136 |
2014 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No ING1 mutations in human brain tumours but reduced expression in high malignancy grades of astrocytoma.
|
14961591 |
2004 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However no significant TSG activity of ING1 was observed while higher activity was reported in different cancer types.
|
25324173 |
2015 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, in a comparison between the cancer and matched normal tissues, a significant decrease in ING1 mRNA expression was found in 17 of 24 (70.8%) breast cancer tissues.
|
10754201 |
2000 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our previous studies using tumor samples from patients have shown that ING1 levels are downregulated in glioblastoma multiforme (GBM), one of the most highly vascularized malignancies.
|
20066899 |
2009 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of p33ING1 mRNA in lymphoid malignancies.
|
10577281 |
1999 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The reduction of mRNA expression in cancer correlated with decreased p33ING1b protein expression (P < 0.0001).
|
15677627 |
2005 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have recently shown that the INhibitor of Growth 1 (ING1) tumor suppressor is down-regulated in malignant gliomas and that the decrease of ING1 expression correlates with histological grade of malignancy, suggesting a role for ING1 in the pathogenesis and progression of malignant gliomas.
|
17763999 |
2008 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It has reported that the expression of p33(ING1) mRNA was decreased in lymphoid malignancies.
|
11835353 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ING1 levels were lower in tumors compared to adjacent normal breast tissue and correlated with tumor size (p=0.019) and distant recurrence (p=0.001) in ER- or Her2+ patients.
|
24962136 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
30 paired normal and tumor tissues were investigated in terms of microdeletion of chromosome 13q33-34 region, ING1 expression and mutation status of ING1 and p53 genes.
|
25324173 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Down regulation and mislocalization of ING1 have been reported in diverse tumor types and Ser/Thr phosphorylation has been implicated in both of these processes.
|
23585863 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both ING1 and ING1L are expressed in a variety of human tissues, but we found ING1L expression to be significantly more pronounced in tumors from several colon-cancer patients than in normal colon tissues excised at the same surgical sites.
|
10072587 |
1998 |